Deblocking Detritylation

Atom Scientific supply high-performance Deblocking and Detritylation reagents from EMP Biotech, designed for the efficient cleavage of the 5’-DMTr protecting group from the terminal nucleotide during oligonucleotide synthesis. These solutions enable rapid deprotection while minimising side reactions and depurination.

Our Range Includes...

DCA & TCA Solutions: Dichloroacetic or trichloroacetic acid in dichloromethane or toluene

Hyacinth Deblocking Solution: 3% DCA in toluene with <30 ppm water, ideal for large-scale, high-purity synthesis

Methylene Chloride & Toluene Blends: Optimised solvent options for various synthesis platforms

AKTA OligoPilot-Compatible Grades: Specially formulated for integration into automated systems

Low Moisture Content: Controlled water levels ensure cleaner reactions and reproducibility