Diisopropylethylamine for Peptide Synthesis

Diisopropylethylamine (DIPEA) is a commonly used organic base in peptide synthesis. It is a colourless liquid with the chemical formula (CH3)2CHCH2N(CH2CH3)2. DIPEA is a tertiary amine, which makes it a strong organic base with a pKa of approximately 11. It is often used as a nucleophilic catalyst to promote peptide bond formation during solid-phase peptide synthesis (SPPS).

DIPEA is commonly used in peptide synthesis because of its high basicity and low nucleophilicity. It can promote the reaction between the carboxyl group of the activated amino acid and the amine group of the growing peptide chain, without interfering with the peptide bond formation. Moreover, DIPEA can enhance the deprotection of the amino acid residues during peptide synthesis by scavenging acidic impurities.

DIPEA is highly purified and free of impurities that may interfere with peptide synthesis reactions. It is compatible with a wide range of peptide synthesis protocols and can be used in various coupling reagents and solvents. DIPEA is also used in other chemical reactions, such as in the synthesis of polymers, drugs, and natural products.

Overall, DIPEA is an important reagent in peptide synthesis and organic chemistry due to its strong basicity, low nucleophilicity, and compatibility with various solvents and coupling reagents.

• Used as a nucleophilic catalyst to promote peptide bond formation during solid-phase peptide synthesis (SPPS).

• Enhances the deprotection of amino acid residues during peptide synthesis by scavenging acidic impurities.

• Highly purified and free of impurities that may interfere with peptide synthesis reactions.

• Compatible with a wide range of peptide synthesis protocols and can be used in various coupling reagents and solvents.

• Also used in other chemical reactions, such as in the synthesis of polymers, drugs, and natural products.

• Acts as a base catalyst in reactions involving carboxylic acids, acid chlorides, and anhydrides.

• Improves reaction rates and yields in various chemical reactions, due to its strong basicity and low nucleophilicity.

Cas Number: 7087-68-5

Einecs Number: 230-392-0

UN Number: 2733

Hazard Class: 3

Hazard Phrases: H225,H302,H318,H331,H335,H411

Prec Phrases: P210,P273,P280,P301+P312,P304+P340+P311,P305+P351+P338