ADTT (5-Amino-3H-1,2,4-dithiazole-3-thione; Xanthane Hydride)

£312.12 to £951.54

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Variation ID	Product Code	Pack Size	List Price	Qty
15642	NC-0305-E100.0-001	100g	£312.12
15643	NC-0305-E500.0-001	500g	£951.54

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The phosphite triester formed in the coupling step can be converted to the corresponding phosphorothioate triester by treatment with 0.2 M solution of phenylacetyl disulfide (PADS) in acetonitrile and 3-picoline (V / V = 1:1).

Typically, a 1.5-column volume of PADS solution is used, and sulphurization is complete within 3 minutes, at which time excess reagent is recovered from the reaction vessel by washing with acetonitrile.

An alternative sulfur-transfer reagent is 3-amino-1,2,4-dithiazole-5-thione (ADTT, also known as Xanthane Hydride) which is suitable for solid-phase synthesis.

Product Name: 5-Amino-3H-1,2,4-dithiazole-3-thione
Molecular Formula: C2H2N2S3
Molecular Weight: 150.25
CAS Number: 6846-31-5
Appearance: Light yellow or yellow powder
Purity by HPLC: ≥ 98.0 %
Water Content (KF Coulometric): ≤ 0.5 %
Identification by IR: The IR spectrum of the test sample should match with the IR spectrum of working standard.
Shipping: Ambient
Storage: Ambient

Application Note
Sulfurizing reagent used in the synthesis of oligonucleotide phosphorothioates.