n,n-Dimethylformamide for Peptide Synthesis

N,N-Dimethylformamide (DMF) is a colourless, high-boiling point, polar aprotic solvent commonly used in peptide synthesis. It has the chemical formula C3H7NO and is known for its solubility power for a wide range of organic and inorganic compounds.

In peptide synthesis, DMF is used to dissolve amino acids and peptide coupling reagents, such as N,N'-dicyclohexylcarbodiimide (DCC) and N-hydroxybenzotriazole (HOBt), which are essential in peptide bond formation. DMF is also commonly used as a solvent for other reagents and additives used in peptide synthesis, such as bases like triethylamine and catalysts like palladium.

The polar aprotic nature of DMF makes it an excellent solvent for reactions that involve polar or charged species. It can also act as a dehydrating agent, helping to remove water from reaction mixtures, which is essential in peptide synthesis, where water can compete with peptide bond formation.

While DMF is an essential solvent for peptide synthesis, it should be handled with care due to its toxic and flammable nature. Prolonged exposure to DMF can lead to respiratory, skin, and eye irritation, and it should only be used in a well-ventilated laboratory with appropriate personal protective equipment.

• Solvent in peptide synthesis for dissolving amino acids and peptide coupling reagents

• Solvent for other reagents and additives used in peptide synthesis, such as bases and catalysts

• Dehydrating agent, helping to remove water from reaction mixtures

• Excellent solvent for reactions that involve polar or charged species

• Used in the production of pharmaceuticals, pesticides, and other chemicals

• Can also be used as a solvent in the manufacture of synthetic leathers, fibers, and films

Cas Number: 68-12-2

Einecs Number: 200-679-5

Hazard Phrases: H226,H312+H332,H319,H360D

Prec Phrases: P210,P280,P303+P361+P353,P304+P340+P312,P305+P351+P338,P308+P313